Much work on the mechanisms and properties of cognition are grounded in the investigation of vision. This post is a conversation we had with Ann-Sophie Barwich and Matt Rodriguez, on the neurophilosophy of olfaction and more generally the “machine” metaphor. I first learned about this work through their excellent paper “Rage against the what? The machine metaphor in biology”.
The recording:
Dr. Barwich’s signature info:
Ann-Sophie Barwich, Ph.D., Assistant Professor, Indiana University, Bloomington, History & Philosophy of Science and Medicine | Cognitive Science
Website | Book 1 | Book 2 | Lab
“A cleric who loses his faith abandons his calling, a philosopher who loses his re-defines his subject.” Ernest Gellner
“The ethical code doesn’t have to win, it doesn’t have to lose either, it has to exist!” Modified after Helmut Schmidt
Some pointers to fascinating work provided by Dr. Barwich:
- Why model system? It’s the background against which most of the following topics emerged (perceptual ambiguity in Ch. 3-4 and 9; biology not chemistry in Ch. 6, non-topography in Ch. 7-8): https://www.hup.harvard.edu/books/9780674278721
- Deconstructing the topographic paradigm in vision for olfaction and pointing to morphological computation via genetic transcription mechanisms: https://osf.io/preprints/psyarxiv/z9jqx
- Linking representational drift to DST (with Gabe, 2023): https://onlinelibrary.wiley.com/doi/10.1111/tops.12689
- Freeman and Skarda 1985: https://www.sciencedirect.com/science/article/abs/pii/0165017385900220
- Kay 2018 on Freeman: https://www.ingentaconnect.com/content/imp/jcs/2018/00000025/f0020001/art00006
- Representational drift 2021: https://www.nature.com/articles/s41586-021-03628-7
- It’s biology, not chemistry! (and why machine learning models have failed thus far; 2022): https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.981294/full
- Two medicinal chemistry papers that fueled the analysis: https://www.nature.com/articles/ncomms11157 and https://pubmed.ncbi.nlm.nih.gov/29487905/
- Perceptual ambiguity (2022; should we model molecules, subjective feelings, or biology?): https://compass.onlinelibrary.wiley.com/doi/full/10.1111/phc3.12883
- Herz and von Clef (same odor, different perception/behavioral): https://pubmed.ncbi.nlm.nih.gov/11374206/
- Eriksson et al 2012 on why some people hate cilantro (mutants!): https://flavourjournal.biomedcentral.com/articles/10.1186/2044-7248-1-22
- Genetics influences perceptual variation: https://www.pnas.org/doi/10.1073/pnas.1804106115
- Mixture coding and allosteric modulation in the olfactory periphery; https://pubmed.ncbi.nlm.nih.gov/23843514/
- 2 reviews of receptor mechanisms: https://pubmed.ncbi.nlm.nih.gov/33409650/ and https://www.frontiersin.org/journals/ecology-and-evolution/articles/10.3389/fevo.2023.1135486/full
- Minimal agent modeling navigational behavior via respiratory feedback: https://direct.mit.edu/isal/proceedings/isal2024/36/33/123516
By the way, our Fieldshift system now includes a new domain in the dropdown menu, giving the ability to convert Abstracts about vision science to the space of olfaction research, try it out!
Featured image courtesy of Midjourney.

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