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new preprint! https://www.biorxiv.org/content/10.1101/2023.01.08.523164v2
Information integration during bioelectric regulation of morphogenesis in the embryonic frog brain. In past work, we’ve found a specific bioelectric pattern (https://www.nature.com/articles/s41467-018-03334-5) required for normal brain
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development. Downstream of this are all the transcriptional cascades required for a good brain. But here’s the key: the correct bioelectric state for proper gene expression is a *spatial pattern* – it’s not the state of single cells, the transcriptional circuits are regulated
by a *difference* between Vmem levels of regions. How do cells sense spatial patterns of voltage across space, to drive the right gene expression downstream? More broadly, how do gene regulatory networks and bioelectric networks interact? What are the information dynamics? Here
we use machine learning to find a model whose behavior matches observed data from the various paper, and then analyze information dynamics. Also the model makes predictions which we confirmed in real embryos. Check out the preprint, because it has a lot of ideas and info which
will surely be removed due to length constraints of journals (argh!).
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whoa just got a rude awakening with respect to how dependent I am not just on email, but on the *timing* of email. Apparently, due to some server glitch, emails I sent between yesterday and today didn’t go out, and others were sent in random order. Total chaos
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ensued, due to my background expectation of emails actually going out when I send them. I can always tell if things aren’t coming in (if the tide slows, I know there’s a problem), but I tend to assume that sent emails actually go out right then. Is there any technological
solution to be somehow alerted if the sending functionality is broken? Maybe some kind of automated thing to send itself an email every so often and complain if the ping email doesn’t come back quickly? Kind of nuts how many things broke by the failure of that one assumption.
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Which ancestor of modern humans would be the 1st one you would be willing to “blame”, e.g. murder, vs. what we say about animals – “that’s just what lions/chimps do, they’re wild animals”. What’s the earliest known being on the tree of life of which you’d be willing to say
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“that one is morally evil”, in appropriate circumstances?